�Expression of protein kinase C? (PKC?) in interneurons of lamina II of the spinal anaesthesia cord dorsal horn is thought to be crucial for mechanically skillful allodynia, a painful response to usually innocuous stimuli. Nonpeptidergic nociceptors were ab initio assumed to innervate PKC? interneurons, because they can in the same sublamina.
Neumann et al. now show that the terminals of nonpeptidergic nociceptor afferents terminate abaxial to the PKC? interneurons, with only when minimal overlap. In contrast, the terminals of metier and large-diameter myelinated afferents overlapped extensively with PKC? neurons, and electron microscopy showed direct synapses between terminals of largediameter, medullated afferents and PKC? interneurons.
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